Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Chem. Commun., 2024, Advance Article DOI: 10.1039/D4CC02028F, Communication Hui-Chao Ma, Hai-Ping Jiang, Zi-Hui Yao, Jun-Feng Tan, Yang-Yang Xing, Gong-Jun Chen, Yu-Bin Dong A novel binaphthyl-based chiral (R)-BHTP-COF was synthesized that can serve as an efficient CSP for HPLC. The COF-packed HPLC columns provide high resolution, selectivity, and durability for the chiral separation of six racemic drugs.