Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution

Chem. Commun., 2024, 60,9785-9788 DOI: 10.1039/D4CC02529F, Communication Bin He, Gen-Qiang Chen, Xumu Zhang We herein report a novel synthetic route for chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding α-halogenated ketones with up to 99% yield, up to >99% dr, and up to 99% ee.