Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling

Thymus is important for shaping T cell immunity, but spatial insights at cellular and molecular level are still scarce. Here the author use multi-omics approaches and custom algorithms to reconstruct the spatial organization of human thymi for both confirming known features and unrevealing new components during thymocyte maturation.