Organocatalytic enantio- and diastereoselective synthesis of trifluoro-ethylamine allenoate derivatives containing axial and central chiralities

Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC03297G, Communication Siyu Shi, Mengyun Gu, Danna Chen, Ruya Li , Zhiqiang Shen, Jinqi Huang, Wenjin Yan Herein, we report an example of a stereoselective γ-addition reaction of trifluoromethyl ketimines to 1-alkynyl ketones mediated by an isothiourea, BTM, under mild conditions, which afforded tetrasubstituted allenes with central...