Enzymatic synthesis of S-adenosyl-L-homocysteine and its nucleoside analogs from racemic homocysteine thiolactone

Chem. Sci., 2024, Accepted Manuscript DOI: 10.1039/D4SC03801K, Edge Article Xiaojin Wen, Viviane Leopold, Florian Peter Seebeck S-adenosyl methionine (SAM)-dependent methyltransferases hold significant potential as tools for the biocatalytic synthesis of complex molecules due to their ability to methylate or alkylate substrates with high regio-, chemo-, and...