Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism

Hyperactivation of the cystic fibrosis transmembrane conductance regulator (CFTR) is central to the pathogenesis of secretory diarrheas and autosomal dominant polycystic kidney disease (ADPKD). Here, authors use cryo-EM to show that inhibitor (R)-BPO-27 inhibits CFTR via pore blockade