Cordycepin: a dual-function molecular element for aptamer engineering with enhanced anticancer activity

Chem. Sci., 2025, Advance Article DOI: 10.1039/D5SC02571K, Edge Article Fei Gao, Li Na, Shuyue Fu, Jinsong Peng, Shipeng He, Ruowen Wang, Weihong Tan This study demonstrates that cordycepin (3′-dA), as a dual-function element, enhances the Sgc8c aptamer's antitumor activity and stability. Sgc8-23A shows improved efficacy in colon cancer models, highlighting its potential for targeted therapy.