Synthesis of γ-Alkylidene Lactones via Molecular Stitching of Carboxylic Acids and Olefins

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC03349G, Edge Article Edis Crnovrsanin, Sourjya Mal, Manuel van Gemmeren In this study, we describe a direct palladium-catalyzed tandem β-C(sp3)–H olefination/lactonization strategy for the one-step synthesis of γ-alkylidene lactones. The reaction is enabled by an N-acyl sulfonamide ligand and utilizes...