1,2-Dihydropyrimidine Synthesis via Titanium-Mediated Multicomponent Coupling of Alkynes, Nitriles, and Aldehydes

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC01979F, Communication Rachel J Dunscomb, Connor W Frye, Xavier Murray, Ian Tonks While dihydropyrimidine cores are found in a number of bioactive molecules, 1,2-dihydropyrimidine regioisomers remain relatively underexplored due to a scarcity of simple synthetic routes to access them. Here, a modular,...