500+ brain scans reveal what LSD, psilocybin, DMT have in common

Psilocybin, LSD, mescaline, DMT, and ayahuasca have different chemical structures, different durations, different cultural histories — and they all do the same thing to the brain. A mega-analysis published in Nature Medicine found a shared two-part pattern across all five drugs: normally tight neural networks weaken internally, while brain regions that usually stay segregated start talking to each other.