REDCAT is a multimodal, all-optical platform that maps metabolic activity alongside cell identity in intact tissues at single-cell and subcellular resolution. By integrating Raman imaging, autofluorescence and high-plex immunofluorescence, REDCAT has resolved metabolic features in normal lymph nodes, uncovered lipid-redox remodeling in lymphoma, and exposed intratumoral heterogeneity, suggesting a use in functional histopathology.