A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegan

A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans

The nuclear hormone receptor NHR-49 regulates nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here the authors show that NHR-49 activity in somatic cells regulates oocyte activation according to nutritional cues.

https://www.nature.com/articles/s41467-026-77056-4 nature.com

RSS Hunter • Aug 22