A transcriptional cofactor GRIP1 drives PPARγ DNA binding and p300-dependent enhancer activity during homeostatic macrophage polarization | Science Advances
Homeostatic macrophages maintain tissue health and resolve inflammation. Upon sustained exposure to type II cytokine IL4, transcription factors STAT6, KLF4, EGR2 and a ligand-regulated nuclear receptor PPARγ orchestrate the M2IL4 ‘polarization’, marked ...
