A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy

Chem. Commun., 2025, Advance Article DOI: 10.1039/D5CC02248G, Communication Guofeng Yi, Jiayi Li, Qiqi Xu, Ying Wang, Chen Peng, Weijun Zhao, Cheng-Yun Wang We report a novel trident-like multi-cation photosensitizer (PS) with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy. Its rational design boosts ROS generation and overcomes PS leakage in biomimetic delivery systems.