ARCaDia: Single-round screening of a DNA-type targeted covalent binder possessing a latent warhead

Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D4CC04594G, Communication Masumi Taki, Masayasu Kuwahara, Chaohui Li, Naoko Tomoda, Naoyuki Miyashita, Tetsuo Kan, Jay Yang A covalent binder for a target protein was obtained by a direct single-round screening of a latent-warhead-modified DNA library via affinity/reactivity-based co-selection of aptameric deoxyribonucleic acid (ARCaDia), followed by a...