BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death

BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death | Science

The apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of BAX-BAK without apoptosome activation triggers sustained ...

https://www.science.org/doi/10.1126/science.aea2181 science.org

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