Carbene-catalyzed enantioselective construction of quasi-symmetrical spirocyclic hydroquinone with minor chiral distinction

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC01605C, Edge Article Panlong Ren, Qing Zhao, Yonggui Robin Chi, Tingshun Zhu Constructing nearly symmetrical chiral center with tiny chiral differences is a challenging task in asymmetric synthesis. As a representative example, natural antibiotic Fredericamycin A (FDM-A) has a unique structure with...