Colorimetric ALP Detection with Ligand-Exchanged Au₈ Cluster

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC02136G, Communication Jingjing Yang, Qing You, Qian Wang, Hongliang Zhao, Yu Cheng, Ming Yao, Junchi Ruan, Yan Zhao, Man-Bo Li, Zhikun Wu An atomically precise Au₈ nanocluster (dppm/dppp) synthesized via ligand exchange exhibits oxidase-like activity. Alkaline phosphatase (ALP) quenches O₂•⁻, enabling sensitive and specific colorimetric detection and demonstrating diagnostic potential.