Concise Total Synthesis of the Cage-Like Sesquiterpenoid (+)-Daphnepapytone A

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC02952J, Edge Article Elijah C. Gonzalez, Isabel de la Torre Roehl, Brian M. Stoltz We report a non-biomimetic total synthesis of (+)-daphnepapytone A, an unprecedented member of the guaiane-derived sesquiterpenoids that displays moderate inhibitory activity against -glycosidase (IC50 = 159 ± 2.1 M) and...