Nature | Chemistry
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De novo design of light-responsive protein–protein interactions enables reversible formation of protein assemblies
Light-responsive proteins hold significant potential in biotechnology but naturally occurring examples are scarce and limited in diversity. Now a totally de novo computational approach has been developed to design light-responsive proteins with diverse architectures by precisely incorporating the non-canonical amino acid phenylalanine-4′-azobenzene (AzoF), which is responsive to light.
