Detecting Microsatellite Instability of Cancer via Multiplexed Orthogonal Gap-Enhanced Raman Tags

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC01912E, Edge Article Guowei Fu, Jin Li, Qian Zhang, Changjun Lv, Zhiyang Zhang, Xiaoyan Wang, Rihui Wu, Lingxin Chen Microsatellite instability (MSI) is a hallmark of colorectal cancer in immunotherapy, whose phenotypes mainly involve four mismatch repair (MMR) proteins (MlH1, MSH2, MSH6 and PMS2). Since these MMR proteins are...