‘Catalytic alkene hydrofunctionalizations typically create a single stereocentre or vicinal stereocentres through a 1,2-addition mechanism. Now it has been shown that 1,3-hydrofunctionalization of unactivated trisubstituted alkenes can be achieved through a directing relay strategy. This process generates enantiopure amide products containing α and γ non-adjacent stereocentres with high diastereoselectivity and enantioselectivity.