Enantioselective Zn-Catalyzed Hydrophosphinylation of Nitrones: An Efficient Approach for Constructing Chiral α-Hydroxyamino-Phosphine Oxides

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC01453K, Edge Article Jun Wang, Shihui Luo, Xinzhu Yuan, Jiangtao Cheng, Zhiping Yang, Zhongxing Huang Although enantioselective hydrofunctionalizations of nitrones are established for synthesis of various types of chiral hydroxylamines, the asymmetric catalytic hydrophosphinylation of nitrones remains highly challenging. Herein, an efficient asymmetric hydrophosphinylation of...