Science Magazine | AAAS: Science Advances Follow Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses | Science Advances p21 acts as a rheostat of DNA replication speed controlling PrimPol- and Pol kappa–dependent nascent DNA synthesis. https://www.science.org/doi/10.1126/sciadv.adw4618 science.org