JAMA | The Latest Medical Research, Reviews, and Guidelines Follow FDA Approves First Acetaminophen and Naproxen Sodium Combination Drug The US Food and Drug Administration (FDA) approved the first pill combining acetaminophen with naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID). https://jamanetwork.com/journals/jama/fullarticle/2853280 jamanetwork.com