Flipping Out: Role of Arginine in Hydrophobic Interactions and Biological Formulation Design

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D4SC08672D, Edge Article Jonathan William Patrick Zajac, Praveen Muralikrishnan, Idris Tohidian, Xianci Zeng, Caryn L Heldt, Sarah L Perry, Sapna Sarupria Arginine has been a mainstay in biological formulation development for decades. To date, the way arginine modulates protein stability has been widely studied and debated. Here, we employed a hydrophobic...