Geminal Homologative Fluorination of Carbonyl Derivatives en route to 1-Fluoro-2-Haloethyl- Skeletons

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC01542A, Communication Margherita Miele, Davide Castiglione, Alexander Roller, Laura Castoldi, Vittorio Pace Carbonyl groups of aldehydes and ketones are conveniently exploited for forging 1-fluoro-2-haloethyl chains through the sequential (nucleophilic) installation of halogenated C1-units and the fluoride anion. This formal gem-difunctionalization of carbonyls...