In this issue of JAMA, Stoppe and colleagues present the results of an international randomized clinical trial that provides evidence that high-dose intravenous vitamin C does not improve outcomes in patients with large burns. The data from the VICTORY trial even suggest that use of vitamin C in patients with large burns might increase mortality. This well-designed study had strict criteria for stopping based on futility or harm. It is clear that the possibility of vitamin C improving outcomes in major burns is extremely low.