Human type-1 innate lymphoid cells control leukemia stem cell differentiation and limit acute myeloid leukemia development

Type 1 Innate Lymphoid cells (ILC1s) regulate the disease progression in murine models of acute myeloid leukaemia (AML). Here, the authors show that human ILC1s are impaired in patients with AML, and human umbilical cord blood-generated ILC1s can inhibit leukemia stem cell differentiation and limit AML development, suggesting a potential therapeutic approach.