Importance of the 3’-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC01562F, Communication Nurgül Bilgin, Laust Moesgaard, Giordano Proietti, Jacob Kongsted, Jasmin Mecinović Acetyl-coenzyme A is a universal coenzyme involved in diverse biochemical reactions, including histone acetylation catalysed by histone lysine acetyltransferases. Combined enzyme assays and molecular dynamics simulations demonstrate that the 3’-phosphate...