Integration of RNAseq transcriptomics and N-glycomics reveal biosynthetic pathways and predict structure-specific N-glycan expression

Chem. Sci., 2025, Advance Article DOI: 10.1039/D5SC00467E, Edge Article Michael Russelle S. Alvarez, Xavier A. Holmes, Armin Oloumi, Sheryl Joyce Grijaldo-Alvarez, Ryan Schindler, Qingwen Zhou, Anirudh Yadlapati, Atit Silsirivanit, Carlito B. Lebrilla glycoPATH integrates RNAseq transcriptomic and LC-MS/MS glycomic data, providing a platform to identify genes implicated in diseases involving N-glycan biosynthesis and enabling the development of targeted therapeutics for these pathways.