Macrocyclic Skeletal Modification Approach to the Anti-Trypanosomal Macrolides, Actinoallolides

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC01915J, Communication Goh Sennari, Akito Watanabe, Takanori Ono, Jun Oshita, Yoshihiko Noguchi, Tomoyasu Hirose, Toshiaki Sunazuka Herein, we report the construction of 16-membered macrocycles that were designed for intermediates toward the unifie synthesis of actinoallolides. Key to our synthesis was the use of Mitsunobu macrocyclization, followed...