Mechanisms of Kobayashi Eliminations for the Generation of Highly-Strained Arynes, Cyclic Cumulenes, and Anti-Bredt Olefins

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC03943F, Edge Article Zach G Walters, Dominick C Witkowski, K. N. Houk, Neil K Garg First disclosed in 1983, the Kobayashi method for generating transient strained intermediates from 1,2-silyltriflate precursors, has become an indispensable tool in organic synthesis. More than 1,300 Kobayashi precursors to strained...