Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, suppressing ChREBPβ and protecting β-cells from glucolipotoxicity, showcasing ‘molecular glues’ as tools to control difficult to target transcription factors.