Nickel-catalyzed sequential 1,2-N-migration/BCBs ring-opening to access spirocyclobutyl β-amino acid esters

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC03029C, Communication Xin-Yu Li, Mei-qiu Xiao, Li-juan Zhou , Jia-qi Zhang, Meng-yan Zhao, Shuo-wen Wang, Shi Tang Hetero-atom migration strategy is a powerful tool to access complex molecules. Herein, we disclosed a cascade radical 1,2-N-migration/ring-opening of N-aryl bicyclobutyl amides (BCBs) with β-bromo α-amino acid esters by cooperative...