Novel tryptophan 2,3-dioxygenase-targeted ruthenium(II)-indole complex activates immunotherapy in vitro and in vivo

Chem. Sci., 2025, Advance Article DOI: 10.1039/D5SC03778F, Edge Article Zheng-Qi Shen, Binglian Guo, Xiangyu Dai, Hanxue Liu, Meng Ren, Peisen Wang, Yating Zhang, Yinuo Xu, Zhi Su, Xuling Xue, Hong-Ke Liu In-Ru, a novel TDO-targeted indole-coordinated Ru(II) arene complex, induces DNA damage and necroptosis, further activates ICD effect and blocks TDO expression, thereby reversing immunosuppression and enhancing the efficacy of immunotherapy.