Nutrient-driven histone code determines exhausted CD8+ T cell fates | Science

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultured with GD2-expressing U-87 MG cancer cells (fig. S4E)...