One-pot, chemoselective desulfurative functionalization of cysteine containing peptides using pyridinium salts

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC01813G, Communication Jeroen W van den Heuvel, Esther Oreoluwa Olaniran Håkansson, Bobo Skillinghaug, Luke R Odell Peptide and protein modifications, especially late-stage derivatization, are invaluable for the synthesis of new pharmaceuticals. Currently, cysteine-mediated peptide modification is mainly limited to bioconjugation and disulfide formation. Therefore, exploration of...