Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells

γδ T cell-based immunotherapies are limited by the reduced expansion and activation of the T cells ex vivo. Here the authors show that garlic nanoparticles can activate IFNγ-producing γδ T cells directly in the intestine, before they translocate to extraintestinal tumours, where they can synergize with anti-PD-L1 therapy, inducing robust antitumour immunity.