Overcoming the solubility crisis: A solvent-free method to enhance drug bioavailability

A large share of medicines developed today may never reach patients for a surprisingly simple reason: they cannot dissolve well enough in water. For most treatments, the oral route remains the gold standard because it is convenient and familiar. However, for a pill to work, its active ingredients must first dissolve in the fluids of the gastrointestinal tract before they can be absorbed into the bloodstream.