Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2

Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer’s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and enables microglia to degrade pre-existing plaques.