Photoactive Monofunctional Pt(II)-Cyanine Complex for Nucleus and Mitochondria Dual-Targeted Antitumor Therapy

Chem. Sci., 2025, Accepted Manuscript DOI: 10.1039/D5SC01616A, Edge Article Ting He, Qiaojv Ren, Yu Zhang, Qinan Tang, Chao Jiang, Yurong Liu, Ziguang Wang, Shan Lei, Yifan Zhang, Peng Huang, Jing Lin Monofunctional platinum (Pt) complexes, characterized by their single reactive site capable of binding to DNA, exhibit distinct mechanisms of action compared to those of currently approved Pt-based chemotherapeutic drugs. Although...