Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli

The disruption of the rhomboid protease gene glpG in E. coli leads to defects in bacterial colonization. Here, the authors show that GlpG is essential for the assembly of type 1 pili, a virulence factor required for colonization of bacteria in eukaryotic cells.