Roche unveiled its innovative sequencing by expansion (SBX) technology at the 2025 ASHG meeting, showcasing advancements in genomics. SBX's speed, flexibility, and longer reads expand research capabilities significantly. Broad Clinical Labs, with Roche, achieved a new Guinness World Record for the fastest DNA sequencing technique, under four hours. The Wellcome Sanger Institute joined as a collaborator, evaluating SBX's potential across research applications. Roche is progressing in methylation mapping using SBX-Duplex and TAPS methods. The University of Tokyo utilized SBX for rapid and accurate spatial sequencing analyses of lung cancer tissue. A target enrichment method using SBX-Simplex showed high throughput and accuracy. These advancements support multiomics research, redefining approaches to disease biology. Collaborations with various institutions highlight SBX's potential. Roche focuses on developing innovative medicines and diagnostics.