SsrA-based design of BacPROTAC for β-lactamase degradation in Gram-negative bacteria

Chem. Commun., 2025, Accepted Manuscript DOI: 10.1039/D5CC02015H, Communication Qi Chang Nie, Jessie Wing-Yin Wu, Kun Zhang, Shu Ling Lin, Carmen Oi Kwan Law, Ying Ying Zhang, Xue Han Wang, Yanjuan Gu, Zhong-Ping Yao, Wing-Tak Wong, Terrence Chi-Kong Lau Antimicrobial resistance (AMR) proliferation and stagnant antibiotic innovation challenge infection control. Bacterial proteolysis-targeting chimeras (BacPROTACs) show promise in degrading resistance factors in Gram-positive pathogens but remain uncharacterized in clinically dominant...