Science Magazine | AAAS: Science Advances Follow STAT3 haploinsufficiency is associated with autosomal dominant hyper-IgE syndrome | Science Advances The heterozygous STAT3 nonsense mutation Y657* leads to haploinsufficiency and AD-HIES–related symptoms. https://www.science.org/doi/10.1126/sciadv.adw2464 science.org
