Stereoselective alkylation of saturated heterocycles

Enantioselective C(sp3)–H alkylation of easily accessible saturated heterocycles is challenging. Now, a nickel-catalysed enantioselective C(sp3)–H alkylation of saturated nitrogen and oxygen heterocycles with olefins has been developed, offering an efficient strategy for the stereoselective formation of C(sp3)–C(sp3) bonds.