Nature | Communications
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Sulfonyl-PYBOX/ErCl3 complex enable highly enantioselective synthesis of α,α-dialkyl and α-alkyl-α-aryl hydrazinonitriles
Authors present an ErCl₃-catalyzed cyanation of both aliphatic and aryl ketone hydrazones for the facile access of C(alpha)-tetrasubstituted alpha-hydrazino nitriles in up to 96% ee, by using a sterically confined pyridinebisoxazoline (PYBOX) ligand featuring a sulfonyl group at the pyridine C4 position.
