Nature | Communications
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Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis
Blood p-tau217 is a leading Alzheimer’s test but is also raised in ALS. Here, the authors show that muscle makes its own form of tau which leaks into the blood, and that detecting brain-derived p-tau217 improves the test’s accuracy.
