Nature | Communications
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The structural mechanism of HIV-2 Vif antagonism of human APOBEC3H
HIV-2 Vif counteracts a broad range of APOBEC3 restriction factors to promote viral infectivity. Here, the authors determine the structure of HIV-2 Vif bound to human APOBEC3H and the host cofactor CBFβ, uncovering a distinct mode of APOBEC3H recognition and dimerization.
